Helicos High Speed Gene Sequencing

boxa888 Says:

Oct 27, 2008 - large scale cell replication?? with some florecent piece lol.

formallyknownasdave Says:

Oct 27, 2008 - @mcfilmmakers Mock commercials in horror/action movies tend to be more cliche than normal commercials. The synthesized woman's voice, making the commercial creepy and evil, but at the same time believable that it had been created to promote something Examples: The umbrella corp. commercial in resident evil, and SkyNet from the terminator (2 I think)

darkein Says:

Oct 27, 2008 - "This was a triumph, I'm making a note here.. huge success. It's hard to overstate my satisfaction" Doesn't the one narrator sound like the person from portal? Robotic at the least.

weylin6 Says:

Oct 27, 2008 - this seems prone to errors...

leeam2k Says:

Oct 28, 2008 - -"WIRD haha! han vuelto a hacerlo.. WIRD!! xD Un momento! esto no es WIRD verdad? ¿¡porque no hay ninguna revista llamada WIRD!?" -"No papa esto es WIRED" jaja aguanten los simpsons

Westonci Says:

Oct 28, 2008 - Hopefully Obama wins the election, because Sarah Palin calls money for scientific research "earmarks"

Truthiness231 Says:

Oct 28, 2008 - Yeah, that's what I thought, I was just making sure I heard things right. It's amazing how genetic engineering is performed these days. ^.^ With the information given by this process, we could eventually compare every known organism with each other and have the best map of evolution ever made (not to mention what this would do for other important fields, particularly medicine, but that's what I'm interested in).

987wolf987 Says:

Oct 29, 2008 - wow ths like really hardcore stuf

MagsterMagpie Says:

Oct 30, 2008 - Fantastic.

magick205 Says:

Nov 1, 2008 - This is absolutly brilliant. However, what's the base and support cost for this beast? Since you have to flush the test cell after each polymerase run, how much material is lost and is any /can any be recycled? It sounds like a great tool, but I don't think that this is gonna show up in any "mom pop clone your dead cat" shops any time soon.

cerman07 Says:

Nov 13, 2008 - are there limits to reconstructing the genome due the 100bp size limit (due to vntrs, transposons)? also, if the average area per polyT binding site is 1 square micron, how accurate can the imaging be?

lockie84 Says:

Nov 24, 2008 - very interesting technology

vitr1ol Says:

Nov 27, 2008 - How are the 100bp sequences put back in order again? presumably you end up with the sequence of each section, but not the whole genome, or even genes if they are longer than 100bp...

RichardPickman Says:

Nov 30, 2008 - Computers! You can use scripts to align the short sequences to each other - you have so much coverage of the genome that each location in the genome is present on many different fragments of DNA. "Stack" these to assemble the longer sequence: ________ ____________ ____ _________ ^^^ we can be pretty sure of this area. Imagine other fragments filling the gaps too!

RichardPickman Says:

Nov 30, 2008 - See my response to vitr1ol above... Any inaccuracies will hopefully sufficiently "covered" that we can call it a random error too, but the imaging is rather precise. It knows where the laser is pointing at any moment and the detection limit is quite low.

vitr1ol Says:

Dec 1, 2008 - Ahh, I see, ingenious.

abbylinda Says:

Dec 5, 2008 - Maybe I would understand it better if I turned the sound on...

XooxerX Says:

Dec 25, 2008 - That's friggen clever as hell! Kudos Helicos!

DisturbedRocks111 Says:

Jan 25, 2009 - i dont understand...what will this accomplish? (go easy on me lol i have no knowledge of genes etc)

redbaronnl1 Says:

Feb 25, 2009 - It accomplishes much faster DNA sequencing. With the old method it took months to do what this technique does within hours

7677890 Says:

Mar 11, 2009 - Basically, you can search someone's DNA for genes which cause disease, just using a few cells.

drmorrisj Says:

Sep 23, 2009 - I disagree with Richard Pickman in terms of the ease of use. This is the problem with the SOLiD. The solid has very short reads (actually 250bp). This makes assembly very difficult. This is why my lab is going with the GS FLX instead of the SOLiD or this cute machine for that matter. They are going to have to do better than this.

belate2 Says:

Oct 19, 2009 - This is a good stock to buy. It's available at a reasonable price as of 10-19-09. It will go bezerk if someone like General Electric buys it up or buys into it. Or it may stand well on its own, leastwise that's what my money says.

Psycatalyst Says:

Nov 5, 2009 - This is just as costly as most other sequencing machines because you got to pay for the fluorescent dNTPs and the Data processing must be a bitch if it does not come with a program. I think the nanopore sequencing may cost lesser

yanij Says:

Nov 11, 2009 - which version of SOLiD are u using? the average bp of SOLiD should be around 50bp rather than 250.